We now offer the latest FDA-approved neuromodulator Daxxify which relaxes facial muscles and smooths facial wrinkles. Daxxify is a new neuromodulator formulated to treat frown lines, the vertical lines that form between the eyebrows. This injectable provides longer-lasting results than Botox and other botulinum toxin neuromodulators. Studies show that effects last up to six months, in comparison to the traditional three to four months for other neuromodulators. 

About Daxxify

DaxibotulinumtoxinA or “Daxi” for short, Daxxify is similar to other neuromodulators such as Botox, Jeuveau, Dysport, and Xeomin. It’s also derived from the bacteria Clostridium botulinum and is used to treat dynamic wrinkles. These are the lines and wrinkles that are caused by the muscle contractions when we smile, frown, squint or even wrinkle our nose. Unfortunately, as we age, these lines become more prominent and visible even when the face is at rest.

Daxxify is a newer treatment that can prevent these pesky lines from setting in. Since it hit the market, it’s attracted attention for its duration and efficacy. Patients need only two treatments per year, as opposed to the three or four that other neuromodulators require to maintain results. The effects of Daxxify have been studied in thousands of individuals, and studies show that the average duration of effect is approximately 5 to 6 months.  Common side effects are similar to those of other neuromodulators, the most common being headaches and mild discomfort at the injection site. 

While Daxxify has only been approved for the treatment of frown lines, it has the potential to treat other facial wrinkles in addition to medical conditions Botox treats. Frown lines appear vertically on the forehead between eyebrows and are also known as glabellar lines, or the “11s.” Daxxify helps to relax the forehead muscles for a calmer, more relaxed look.

How does Daxxify compare to Botox?

Both Botox and Daxxify block the nerve signals that cause facial muscles to contract. These contractions form “dymamic” wrinkles on the face because of repeated movement. Botox and DAXXIFY are produced differently, however and contain different forms of botulinum toxin.  Botox is made with onabotulinumtoxinA, while Daxxify contains daxibotulinumtoxinA, a more highly purified form of the toxin. 

Injectable neurotoxins are formulated with proteins that help keep the active ingredients stable, so that they will be effective after they’ve been reconstituted in the vial and prepared for injection. These proteins bind to the toxin molecules so that they are evenly distributed in the solution. After it’s been injected into the muscle, the toxins bind to the neuromuscular junction: where the nervous system communicates with the muscles. Once there, it blocks the release of acetylcholine, the chemical that signals the muscle to contract. Muscles don’t get the message, and skin stays smooth.

Daxxify is formulated with a special peptide that is positively charged. Just like your hair sticks to a balloon, this results in an electrostatic charge that allows it to better “cling” to the part of the nerve tissue that communicates with the muscle. Botox on the other hand, requires the addition of human serum albumin to keep it stable. DAXXIFY eliminates the need to use human or animal products like other neurotoxins. The use of DAXXIFY also allows it to work more effectively for a longer period of time.

Currently, Daxxify is FDA-approved to treat glabellar lines, while Botox is FDA-approved for the treatment of glabellar lines; forehead lines; crow’s feet; and medical issues such as upper limb spasticity, cervical dystonia, overactive bladder, and excessive sweating. 

Benefits of Daxxify include: 

• Smooths frown lines
• Quick and convenient procedure
• No use of human or animal products
• Safe formulation with proprietary stabilizing peptides
• May have other cosmetic and medical uses as research continues
• Injections last up to six months, longer than all other neuromodulators

Candidates

You may be a good candidate for Daxxify if you are generally in good health and haven’t had adverse reactions to other neurotoxins. Candidates should not be pregnant or breastfeeding. This procedure is ideal for patients familiar with injectable treatments and who desire the convenience of fewer follow-up treatments for maintenance. 

Since Daxxify lasts about six months, patients should be aware that neurotoxins cannot be reversed after injection, so they will have to wait until the injectable wears off naturally. 

To learn more about Daxxify and treatment options, contact Greenbrae Dermatology to schedule a consultation.